SafariPlus is a great tool if you're looking for an advanced way of managing your cookies. Available via the system preferences menu, SafariPlus has its own interface window, from which you can view cookies for all the sites you've visited.
Set favorite websites and get SafariPlus to remove all non-favorites or simply check individually all the ones that you wish to remove.
SafariPlus does more than just handling cookies in Safari.
You'll also be able to decide whether or not to display Flash and GIF animations in the browser. I personally always block these elements, to avoid having too many animations playing in Safari.
It's also a safer way of browsing the web in general.
SafariPlus is a very handy extension to have, the only drawback being that it doesn't seem to be Leopard ready.
However we can expect for a new version to be on hand soon.
SafariPlus lets you manage cookies and Flash and GIF animations in the Safari web browser.